C003P: Adalimumab Biosimilar, TNF alpha Monoclonal Antibody

Recombinant Humanized IgG1 Monoclonal Antibody.
Specificity/Sensitivity: The monoclonal antibody adalimumab biosimilar specifically binds to the human TNF alpha.
Applications: ELISA, flow cytometry, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by adalimumab.

PA007158.m1: In Vivo Grade Recombinant Anti-DNP Mouse IgG1 Kappa Isotype Control Antibody (mIgG1 Isotype Control)

The in vivo grade recombinant anti-DNP mouse IgG1 isotype control antibody (clone of DNP.m1) was produced in mammalian cells.
Applications: an isotype-matched negative control for anti-DNP mouse IgG1 kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

Please contact us to ask for a quote for the engineered DNP isotype control mutants, isotype control and mutants with Avi-, His-, and Flag-tags, and biotinylated isotype control and mutants. A variety of conjugates (such as dyes and fluorophores) with the anti-DNP isotype control and mutants are available.

PA007162.mm2c: In Vivo Grade Recombinant Murinized Anti-mouse PD-1 Mouse IgG2c-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone RMP1-14.1)

The in vivo grade recombinant murinized anti-mouse PD-1 / CD279 monoclonal antibody (mouse IgG2c-LALAPG kappa) was produced in mammalian cells.
Applications: immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007162.r2a: In Vivo Grade Recombinant Anti-mouse PD-1 Rat IgG2a Kappa Monoclonal Antibody (Clone RMP1-14.1)

The in vivo grade recombinant anti-mouse PD-1 / CD279 monoclonal antibody (rat IgG2a kappa) was produced in mammalian cells.
Applications: immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007162.m2cLA: In Vivo Grade Recombinant Anti-mouse PD-1 Mouse IgG2c-L234A L235A P329G (LALAPG) Kappa Monoclonal Antibody (Clone RMP1-14.1)

The in vivo grade recombinant anti-mouse PD-1 / CD279 monoclonal antibody (mouse IgG2c-LALAPG kappa) was produced in mammalian cells.
Applications: immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007152.m2a: In Vivo Grade Recombinant C1.18.4 Mouse IgG2a Kappa Isotype Control Antibody (mIgG2a Isotype Control)

The in vivo grade recombinant C1.18.4 mouse IgG2a isotype control antibody was produced in mammalian cells.
Applications: an isotype-matched negative control for mouse IgG2a kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

Please contact us to ask for a quote for the engineered C1.18.4 isotype control mutants, isotype control and mutants with Avi-, His-, and Flag-tags, and biotinylated isotype control and mutants. A variety of conjugates (such as dyes and fluorophores) with the C1.18.4 isotype control and mutants are available.

Experienced scientists working on antigen and antibody production, antibody engineering, lentivirus, and cell line development services for decades. >90% success rate of stable cell line generation.

Fast turnaround:

Antigen (peptide or protein) production: 3-6 weeks.
Mouse monoclonal antibody production: 20-24 weeks.
Screening phage or yeast libraries for fully human antibodies: 8-12 weeks.
Sequencing hybrioma antibody: 1-3 weeks.
Chimeric antibody production: 3-4 weeks.
Antibody humanization: 8-10 weeks.
Construction of CAR cassette, lentivirus packaging and production: 4-5 weeks.
T-cell activation, transduction, and CAR T-cell expansion: 4-5 weeks.
Confirmation of CAR expression, IFN-gamma ELISA, and cytotoxicity assay of transduced and expanded T-cells: 2 weeks.

PA007187: In Vivo Grade Recombinant Chimeric Human IgG1 kappa Isotype Control Antibody

The in vivo grade recombinant chimeric human IgG1 isotype control antibody was produced in CHO cells.
Applications: an isotype-matched negative control for human IgG1 kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007188: In Vivo Grade Recombinant Chimeric Human IgG1-D265A kappa Isotype Control Antibody

The in vivo grade recombinant chimeric human IgG1-D265A kappa isotype control mutant was produced in mammalian cells.
Applications: an isotype-matched negative control for human IgG1 D265A kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007189: In Vivo Grade Recombinant Chimeric Human IgG1-N297A kappa Isotype Control Antibody

The in vivo grade recombinant chimeric human IgG1-N297A kappa isotype control mutant was produced in mammalian cells.
Applications: an isotype-matched negative control for human IgG1 N297A kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007190: In Vivo Grade Recombinant Chimeric Human IgG1-L234A L235A P329G (hIgG1 LALAPG) kappa Isotype Control Antibody

The in vivo grade recombinant chimeric human IgG1-L234A L235A P329G (hIgG1 LALAPG, Fc silenced) kappa isotype control mutant was produced in CHO cells.
Applications: an isotype-matched negative control for human IgG1 LALAPG kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007191: In Vivo Grade Recombinant Chimeric Human IgG1-D265A N297A (hIgG1 DANA) kappa Isotype Control Antibody

The in vivo grade recombinant chimeric human IgG1-D265A N297A (hIgG1 DANA) kappa isotype control mutant was produced in mammalian cells.
Applications: an isotype-matched negative control for human IgG1 DANA kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

PA007192: In Vivo Grade Recombinant Chimeric Human IgG1-S267E L328F (hIgG1 SELF) kappa Isotype Control Antibody

The in vivo grade recombinant chimeric human IgG1-S267E L328F (hIgG1 SELF, Fc activated) kappa isotype control mutant was produced in mammalian cells.
Applications: an isotype-matched negative control for human IgG1 SELF kappa antibodies used in ELISA, Western Blot (WB), Flow Cytometry (Flow), Immunoprecipitation (IP), Immunohistochemistry (Paraffin) (IHC (P)), Immunohistochemistry (Frozen) (IHC (F)), and in vivo animal model research.
Endotoxin Level: Less than 1 EU/mg of protein as determined by LAL method.

- Any gene;
- Any host cell, including primary cell;
- Highly efficient and precise.

Fast turnaround:

Knock-out cell line generation: 16-19 weeks.
Knock-in cell line generation: 20-24 weeks.

Experienced scientists working on antibody and cell line development services for decades. >90% success rate of stable cell line generation.

Stable cell lines developed with our proprietary recombinant antibody expression system with multiple selectable markers is very productive in expressing target proteins.

Fast turnaround:

Basic service: 7-8 weeks.
Premium service: 12-14 weeks.
Pool cells: 6 weeks.

Experienced scientists working on protein engineering, expression, and purification, and cell line development services for decades. >90% success rate of stable cell line generation.

Stable cell lines developed with our proprietary protein expression system with multiple selectable markers is very productive in expressing target proteins.

Fast turnaround:

1 week for synthesizing a gene for expressing the target protein.
1 week for molecular construction of the gene.
5-6 weeks for generation of suspension CHO stable cell lines expressing the target protein.
5-6 weeks for additional services included in the premium package.